TTL Monoclonal antibody, PBS Only
TTL Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
human, mouse, rat, pig
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2E5F8
Cat no : 66076-1-PBS
Synonyms
Validation Data Gallery
Product Information
66076-1-PBS targets TTL in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Reactivity | human, mouse, rat, pig |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | TTL fusion protein Ag4708 |
Full Name | tubulin tyrosine ligase |
Calculated Molecular Weight | 377 aa, 43 kDa |
Observed Molecular Weight | 43 kDa |
GenBank Accession Number | BC036819 |
Gene Symbol | TTL |
Gene ID (NCBI) | 150465 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Tubulin-tyrosine ligase (TTL) is the enzyme responsible for the reversible addition of a tyrosine residue at the carboxyl end of alpha-tubulin. TTL forms stable complexes with tubulin and inhibit tubulin polymerization. TTL is frequently suppressed during tumor progression with resulting accumulation of detyrosinated alpha-tubulin in tumor cells. TTL suppression in human cancers is associated with increased tumor aggressiveness.