TREM2 Monoclonal antibody, PBS Only
TREM2 Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1F4H10
Cat no : 68723-1-PBS
Synonyms
Validation Data Gallery
Product Information
68723-1-PBS targets TREM2 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | TREM2 fusion protein Ag6843 |
Full Name | triggering receptor expressed on myeloid cells 2 |
Calculated Molecular Weight | 222 aa, 25 kDa |
Observed Molecular Weight | 26-32 kDa |
GenBank Accession Number | BC032362 |
Gene Symbol | TREM2 |
Gene ID (NCBI) | 54209 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TREM2 (triggering receptor expressed on myeloid cells 2) is a cell surface receptor belongs to TREM family that is expressed on osteoclast, dendritic cells, macrophages, nature killers, neutrophils and microglia (PMID: 19302484). TREM2 is localized predominantly in the Golgi complex, but also shuttles to and from the cell surface in endocytic and exocytic vesicles (PMID: 16675145). TREM2 associates with DAP12 to initiate the intracellular signalling cascade via an immunoreceptor tyrosine-based activation motif (ITAM) domain and tyrosine-kinases (PMID: 23977213). TREM2 has a calculated molecular mass of ~25kDa, but apparent molecular mass of ~40kDa (PMID: 24078628). In addition, TREM2 has a soluble form termed as sTREM-2 with molecular weights ranging between about 24kDa and 40kDa (PMID: 18790823). Loss-of-function mutations in either TREM2 or DAP12 can cause Nasu-Hakola disease (PMID: 19302484).