TREM2 Polyclonal antibody

TREM2 Polyclonal Antibody for WB, FC, ELISA

Host / Isotype

Rabbit / IgG


Human, mouse and More (1)





Cat no : 27599-1-AP


TREM 2, TREM2, Trem2a, Trem2b, Trem2c

Tested Applications

Positive WB detected inMKN-45 cells, THP-1 cells
Positive FC detected inBV-2 cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Flow Cytometry (FC)FC : 0.40 ug per 10^6 cells in a 100 µl suspension
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

27599-1-AP targets TREM2 in WB, IF, FC, IHC, ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TREM2 fusion protein Ag26319
Full Name triggering receptor expressed on myeloid cells 2
Calculated Molecular Weight 222 aa, 25 kDa
Observed Molecular Weight38 kDa
GenBank Accession NumberBC032362
Gene Symbol TREM2
Gene ID (NCBI) 54209
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TREM2 (triggering receptor expressed on myeloid cells 2) is a cell surface receptor belongs to TREM family that is expressed on osteoclast, dendritic cells, macrophages, nature killers, neutrophils and microglia (PMID: 19302484). TREM2 is localized predominantly in the Golgi complex, but also shuttles to and from the cell surface in endocytic and exocytic vesicles (PMID: 16675145). TREM2 associates with DAP12 to initiate the intracellular signalling cascade via an immunoreceptor tyrosine-based activation motif (ITAM) domain and tyrosine-kinases (PMID: 23977213).


Product Specific Protocols
WB protocol for TREM2 antibody 27599-1-APDownload protocol
FC protocol for TREM2 antibody 27599-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Cell Death Dis

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study.

Authors - Wen-Jin Chen

Sci Adv

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

Authors - Rui Sun

Front Immunol

Identification of TREM2-positive tumor-associated macrophages in esophageal squamous cell carcinoma: implication for poor prognosis and immunotherapy modulation

Authors - Hongmu Li

Nat Commun

Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease

Authors - Xingyu Zhang

Brain Res

TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders

Authors - Jingjing Shi

Cell Death Dis

TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits

Authors - Nannan Zhang