|Sample-dependent, check data in validation data gallery|
12809-1-AP targets TRAF6 in WB, IF, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse, rat, sheep|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TRAF6 fusion protein Ag3555|
|Full Name||TNF receptor-associated factor 6|
|Calculated molecular weight||522 aa, 60 kDa|
|GenBank accession number||BC031052|
|Gene ID (NCBI)||7189|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.
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