Anti-Human TNFRSF13B/CD267 Rabbit Recombinant Antibody, PBS Only

TNFRSF13B/CD267 Uni-rAb^TM Recombinant Antibody for FC, Cytometric bead array, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241317D8

Cat no : 98100-1-PBS

Synonyms

CD267, TNFRSF13B, TACI, CVID, 241317D8

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Validation Data Gallery

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  FC experiment of human PBMCs using 98100-1-RR (same clone as 98100-1-PBS)

  1x10^6 human PBMCs were stained with CoraLite® Plus 647 Anti-Human CD19 (4G7) Mouse IgG2a Recombinant Antibody (CL647-65562, Clone: 4G7) and 0.25 ug Anti-Human TNFRSF13B/CD267 Rabbit Recombinant Antibody (98100-1-RR, Clone:241317D8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), or Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 98100-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98100-1-RR (same clone as 98100-1-PBS)

  1x10^6 human PBMCs were stained with 0.25 ug Anti-Human TNFRSF13B/CD267 Rabbit Recombinant Antibody (98100-1-RR, Clone:241317D8)(red)and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), or Isotype Control(blue). Cells were not fixed. This data was developed using the same antibody clone with 98100-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98100-1-RR (same clone as 98100-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human TNFRSF13B/CD267 Rabbit Recombinant Antibody (98100-1-RR, Clone:241317D8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), and 0.25 ug CoraLite® Plus 647 Anti-Human CD19 (4G7) Mouse IgG2a Recombinant Antibody (CL647-65562, Clone: 4G7), and 0.25 ug Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 98100-1-PBS in a different storage buffer formulation.

• 

  Cytometric bead array standard curve of MP01167-1

  Cytometric bead array standard curve of MP01167-1, TNFRSF13B/CD267 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84266-1-PBS. Detection antibody: 98100-1-PBS. Standard: RP02325. Range: 0.313-40 ng/mL.

• 

  Affinity and Kinetic Characterization of 98100-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98100-1-RR against Human TNFRSF13B/CD267 were performed. The affinity constant is 4.18 nM.

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Product Information

98100-1-PBS targets TNFRSF13B/CD267 as part of a matched antibody pair:

MP01167-1: 84266-1-PBS capture and 98100-1-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant Protein
• Full Name: tumor necrosis factor receptor superfamily, member 13B
• Calculated Molecular Weight: 293 aa, 32 kDa
• GenBank Accession Number: BC109392
• Gene Symbol: TNFRSF13B/CD267
• Gene ID (NCBI): 23495
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as CD267 or TACI, is a transmembrane protein of the TNF receptor superfamily found predominantly on B cells (PMID: 10920230). TACI is also expressed on activated T cells, myeloma cells, and expressed by monocytes intracellularly at a low level (PMID: 11429548; 16825497). TNFRSF13B is a receptor for TNFSF13/APRIL/CD256 and TNFSF13B/BAFF/CD257 and mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-κB and AP-1 (PMID: 10956646; 10973284; 9311921). It is involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.