|Positive WB detected in||A549 cells, HeLa cells, HepG2 cells|
|Positive IF detected in||HepG2 cells|
|Western Blot (WB)||WB : 1:1000-1:5000|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
14424-1-AP targets TAX1BP1 in WB, IF, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TAX1BP1 fusion protein Ag5789|
|Full Name||Tax1 (human T-cell leukemia virus type I) binding protein 1|
|Calculated molecular weight||91 kDa|
|Observed molecular weight||90 kDa|
|GenBank accession number||BC050358|
|Gene ID (NCBI)||8887|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
TAX1BP1 (also named as T6BP and TXBP151) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 binds TRAF6 but not TRAFs 1-5.
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.
PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles.