SORLA Polyclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

SORLA Polyclonal Antibody for WB, IHC, IF-P, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF-P, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 22592-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 22592-1-AP (SORLA antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

  IP result of anti-SORLA (IP:22592-1-AP, 5ug; Detection:22592-1-AP 1:500) with mouse brain tissue lysate 10000ug. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 22592-1-AP (SORLA antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 22592-1-AP (SORLA antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

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  IHC staining of human brain using 22592-1-AP (same clone as 22592-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain slide using 22592-1-AP (SORLA antibody at dilution of 1:50. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human brain using 22592-1-AP (same clone as 22592-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain slide using 22592-1-AP (SORLA antibody at dilution of 1:50. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat brain using 22592-1-AP (same clone as 22592-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 22592-1-AP (SORLA antibody at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat brain using 22592-1-AP (same clone as 22592-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 22592-1-AP (SORLA antibody at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

• 

  IF Staining of mouse cerebellum using 22592-1-AP (same clone as 22592-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using SORLA antibody (22592-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

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Product Information

22592-1-PBS targets SORLA in WB, IHC, IF-P, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: SORLA fusion protein Ag18445
• Full Name: sortilin-related receptor, L(DLR class) A repeats-containing
• Calculated Molecular Weight: 2214 aa, 248 kDa
• Observed Molecular Weight: 300 kDa
• GenBank Accession Number: BC137171
• Gene Symbol: SORLA
• Gene ID (NCBI): 6653
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)