Phospho-APP (Thr668) Polyclonal antibody

Phospho-APP (Thr668) Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG







Cat no : 28788-1-AP


A4, AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, amyloid precursor protein, Amyloid-beta precursor protein, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, Phospho-APP (Thr668), PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta

Tested Applications

Positive WB detected innocodazole treated SH-SY5Y cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:3000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

28788-1-AP targets Phospho-APP (Thr668) in WB, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name amyloid beta (A4) precursor protein
Observed Molecular Weight110 kDa
GenBank Accession NumberBC065529
Gene Symbol APP
Gene ID (NCBI) 351
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Amyloid precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain(PMID: 25719338). APP is expressed in many tissues and concentrated in the synapses of neurons. The molecular weight of APP is 100-140 kDa due to the existence of several isoforms. The phosphorylation of APP at Thr668 is involved in the pathogenesis of Alzheimer's disease (AD). The Phospho-APP Thr668 form is neuron‐specific, highly expressed in dystrophic neurites and amyloid plaques of Alzheimer disease, and induces neurodegeneration(PMID: 27076121).


Product Specific Protocols
WB protocol for Phospho-APP (Thr668) antibody 28788-1-APDownload protocol
Standard Protocols
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