PTPIP51 Polyclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

PTPIP51 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 20641-1-PBS

Synonyms

FAM82A2, Protein FAM82A2, hucep-10, hRMD-3, hRMD 3

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Validation Data Gallery

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  WB analysis using 20641-1-AP (same clone as 20641-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20641-1-AP (PTPIP51 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20641-1-PBS in a different storage buffer formulation.

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  IP experiment of HEK-293 using 20641-1-AP (same clone as 20641-1-PBS)

  IP result of anti-PTPIP51 (IP:20641-1-AP, 4ug; Detection:20641-1-AP 1:1000) with HEK-293 cells lysate 1100ug. This data was developed using the same antibody clone with 20641-1-PBS in a different storage buffer formulation.

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  IHC staining of human skin using 20641-1-AP (same clone as 20641-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skin using 20641-1-AP (PTPIP51 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 20641-1-PBS in a different storage buffer formulation.

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  IHC staining of human skin using 20641-1-AP (same clone as 20641-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skin using 20641-1-AP (PTPIP51 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 20641-1-PBS in a different storage buffer formulation.

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  IHC staining of human paracancerous of skin cancer using 20641-1-AP (same clone as 20641-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human paracancerous of skin cancer slide using 20641-1-AP (PTPIP51 antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20641-1-PBS in a different storage buffer formulation.

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  IHC staining of human cervical cancer using 20641-1-AP (same clone as 20641-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human cervical cancer using 20641-1-AP (PTPIP51 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 20641-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human cervical cancer using 20641-1-AP (same clone as 20641-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human cervical cancer using 20641-1-AP (PTPIP51 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 20641-1-PBS in a different storage buffer formulation.

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Product Information

20641-1-PBS targets PTPIP51 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: PTPIP51 fusion protein Ag14708
• Full Name: family with sequence similarity 82, member A2
• Calculated Molecular Weight: 470 aa, 52 kDa
• Observed Molecular Weight: 52-60 kDa
• GenBank Accession Number: BC008970
• Gene Symbol: PTPIP51
• Gene ID (NCBI): 55177
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

Protein tyrosine phosphatase-interacting protein 51 (PTPIP51),also known as RMDN3, is a mitochondrial membrane-anchored protein that interacts with ER membrane-bound VAPB. The VAPB-PTPIP51 interaction impacts on intracellular Ca2+ handling (PMID: 22131369, 28345618). PTPIP51 participates in multiple cellular processes, and dysfunction of PTPIP51 is implicated in diseases such as cancer and neurodegenerative disorders (PMID: 28345618). The known initiation sites in the Ptpip51 gene would lead to molecular protein masses of 52, 38 and 30 kDa (PMID: 18854601,19844996).