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  • KD/KO Validated

PCBP2 Polyclonal antibody

PCBP2 Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human and More (1)





Cat no : 15070-1-AP


Alpha CP2, hnRNP E2, HNRPE2, PCBP2, poly(rC) binding protein 2

Tested Applications

Positive WB detected inHeLa cells, Jurkat cells
Positive IHC detected inhuman testis tissue, human cervical cancer tissue, human colon tissue, human liver tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:6000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

15070-1-AP targets PCBP2 in WB, IF, IHC, CoIP, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PCBP2 fusion protein Ag7102
Full Name poly(rC) binding protein 2
Calculated Molecular Weight 39 kDa
Observed Molecular Weight 43 kDa
GenBank Accession NumberBC001155
Gene Symbol PCBP2
Gene ID (NCBI) 5094
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Poly(rC)-binding protein 2 (PCBP2) is a single-stranded nucleic acid binding protein that binds preferentially to oligo dC, It is also named Heterogeneous nuclear ribonucleoprotein E2, binds also poly(rU). It negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.(19881509) This antibody can recognize PCBP2 and PCBP1.


Product Specific Protocols
WB protocol for PCBP2 antibody 15070-1-APDownload protocol
IHC protocol for PCBP2 antibody 15070-1-APDownload protocol
IF protocol for PCBP2 antibody 15070-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Commun

PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.

Authors - Haiyan Gu
  • KD Validated

Virol Sin

Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3Cpro.

Authors - Huimin Xiao

Mol Cancer Res

PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.

Authors - Xiaonan Wang
  • KD Validated

Vet Microbiol

Cellular poly(C) binding protein 2 interacts with porcine epidemic diarrhea virus papain-like protease 1 and supports viral replication.

Authors - Pengfei Zhang
  • KD Validated
ratWB, IHC

Cell Mol Neurobiol

Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury.

Authors - Zhigang Chen

FEBS Open Bio

Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2.

Authors - Changyu Chen
  • KD Validated