NR1H2 Polyclonal antibody

• Featured Product
• KD/KO Validated

NR1H2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF, IP, ELISA

Conjugate

Unconjugated

Publications

10

Cat no : 14278-1-AP

Synonyms

Liver X receptor beta, LXR b, LXRB, NER, NER I, NR1H2, Nuclear receptor NER, Oxysterols receptor LXR beta, RIP15, UNR

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Validation Data Gallery

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  WB analysis of mouse liver using 14278-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 14278-1-AP (NR1H2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Published Applications

• KD/KO: See 2 publications below
• WB: See 10 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Product Information

14278-1-AP targets NR1H2 in WB, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: NR1H2 fusion protein Ag5635
• Full Name: nuclear receptor subfamily 1, group H, member 2
• Calculated Molecular Weight: 51 kDa
• Observed Molecular Weight: 50 kDa, 40 kDa
• GenBank Accession Number: BC047750
• Gene Symbol: NR1H2
• Gene ID (NCBI): 7376
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Publications

Species	Application	Title
mouse	WB	Nat Immunol; Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27.; Authors - Heeju Ryu
mouse	WB	Br J Pharmacol; Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.; Authors - Chuanrui Ma
mouse	WB	Int J Cancer; Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production.; Authors - Xingzhe Ma ; KD Validated
mouse	WB	Sci Rep; Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice.; Authors - Qixue Wang
human	WB, IF	J Biol Chem; Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II.; Authors - Mengyang Liu
mouse	WB	Biochem J; Identification of interferon-γ as a new molecular target of liver X receptor.; Authors - Qixue Wang ; KD Validated