MTMR2 Monoclonal antibody, PBS Only

• Featured Product
• KD/KO Validated

MTMR2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Pig

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B11B7

Cat no : 67312-1-PBS

Synonyms

CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2

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Validation Data Gallery

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  WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

  WB result of MTMR2 antibody (67312-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTMR2 transfected HeLa cells. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

• 

  WB analysis of pig brain using 67312-1-Ig (same clone as 67312-1-PBS)

  pig brain tissue were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HEK-293 using 67312-1-Ig (same clone as 67312-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

• 

  WB analysis of Jurkat using 67312-1-Ig (same clone as 67312-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

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Product Information

67312-1-PBS targets MTMR2 in WB, Indirect ELISA applications and shows reactivity with Human, Pig samples.

• Tested Reactivity: Human, Pig
• Host / Isotype: Mouse / IgG2b
• Class: Monoclonal
• Type: Antibody
• Immunogen: MTMR2 fusion protein Ag28413
• Full Name: myotubularin related protein 2
• Calculated Molecular Weight: 73 kDa
• Observed Molecular Weight: 66-73 kDa
• GenBank Accession Number: BC052990
• Gene Symbol: MTMR2
• Gene ID (NCBI): 8898
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.