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MIER3 Polyclonal antibody, PBS Only

MIER3 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 17543-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse uterus tissue using MIER3 Polyclonal antibody (17543-1-AP)

    WB analysis of mouse uterus using 17543-1-AP (same clone as 17543-1-PBS)

    mouse uterus tissue were subjected to SDS PAGE followed by western blot with 17543-1-AP (MIER3 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17543-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of mouse uterus tissue using MIER3 Polyclonal antibody (17543-1-AP)

    WB analysis of mouse uterus using 17543-1-AP (same clone as 17543-1-PBS)

    mouse uterus tissue were subjected to SDS PAGE followed by western blot with 17543-1-AP (MIER3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17543-1-PBS in a different storage buffer formulation.

Product Information

17543-1-PBS targets MIER3 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MIER3 fusion protein Ag11604
Full Name mesoderm induction early response 1, family member 3
Calculated Molecular Weight 522 aa, 59 kDa
Observed Molecular Weight 55 kDa
GenBank Accession NumberBC041348
Gene Symbol MIER3
Gene ID (NCBI) 166968
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The mesoderm induction early response (MIER) protein family is known as fibroblast growth factor (FGF)-regulated immediate-early protein family. Activated by FGF, MIER proteins may have a pivotal role in FGF-regulated cellular activities, indicating a potential influence in the progression of certain cancers [PMID:15117948]. MIER3 localizes to the nucleus and primarily functions as a transcriptional repressor. Rat mammary carcinoma susceptibility 1b (Mcs1b) is a quantitative trait locus on RN02 that confers decreased susceptibility when Copenhagen (COP)-resistant alleles are introgressed into a Wistar Furth (WF)-susceptible genome. MIER3 is a candidate Mcs1b gene [PMID:22993404].