- Featured Product
- KD/KO Validated
MGP Polyclonal antibody
MGP Polyclonal Antibody for IF, IHC,ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse and More (1)
Applications
WB, IHC, IF, ELISA
Conjugate
Unconjugated
Cat no : 10734-1-AP
Synonyms
Validation Data Gallery
Applications:
Tested Applications
| Positive IHC detected in | human breast hyperplasia tissue, human breast cancer tissue, human colon cancer tissue, human lymphoma tissue, human small intestine tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF detected in | mouse kidney tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:200-1:800 |
| Immunofluorescence (IF) | IF : 1:50-1:500 |
| Sample-dependent, check data in validation data gallery | |
Published Applications
| KD/KO | See 3 publications below |
| WB | See 18 publications below |
| IHC | See 9 publications below |
| IF | See 6 publications below |
Product Information
10734-1-AP targets MGP in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | MGP fusion protein Ag1091 |
| Full Name | matrix Gla protein |
| Calculated molecular weight | 103 aa, 13 kDa |
| GenBank accession number | BC005272 |
| Gene symbol | MGP |
| Gene ID (NCBI) | 4256 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Matrix Gla protein (MGP), a vitamin K-dependent protein, is recognized as a calcification inhibitor in vascular tissue. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for MGP antibody 10734-1-AP | Download protocol |
| IF protocol for MGP antibody 10734-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Cancer Manag Res Identification of Chemoresistance-Associated Key Genes and Pathways in High-Grade Serous Ovarian Cancer by Bioinformatics Analyses. | ||
Neurosci Lett Differential gene expression analysis of human entorhinal cortex support a possible role of some extracellular matrix proteins in the onset of Alzheimer disease. | ||
Bioengineered Inflammation promotes erythropoietin induced vascular calcification by activating p38 pathway. | ||
Urology High concentration of calcium promotes mineralization in NRK52E cells via inhibiting the expression of matrix Gla protein.
| ||
Calcif Tissue Int Characterization of dystrophic calcification induced in mice by cardiotoxin. |
