|Positive WB detected in||NIH/3T3 cells, HEK-293 cells, mouse liver tissue|
|Western Blot (WB)||WB : 1:500-1:1000|
|Sample-dependent, check data in validation data gallery|
The immunogen of 24064-1-AP is Matrilin 2 Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse|
|Cited Reactivity||mouse, zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Matrilin 2 fusion protein Ag21113|
|Full Name||matrilin 2|
|Calculated molecular weight||107 kDa|
|Observed molecular weight||120-150 kDa|
|GenBank accession number||BC010444|
|Gene ID (NCBI)||4147|
|Purification Method||Antigen Affinity purified|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
The matrilins represent a new family of oligomeric non-collagenous extracellular matrix proteins that are assumed to act as adapter molecules connecting other proteins and proteoglycans in the extracellular matrix (PMID: 17513098). Four matrilins (matrilin-1, -2, -3, and -4) have been identified. They all share a structure made up of von Willebrand factor A domains, EGF-like domains and a coiled-coil alpha-helical module (PMID: 18386166). Matrilin-1 and matrilin-3 are expressed mainly in cartilage, while matrilin-2 and matrilin-4 show broader tissue distribution. Matrilin-2 is the largest member of the family. It incorporates into loose and dense connective tissue and becomes associated with some basement membranes (PMID: 17513098).
A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations.
J Mol Med (Berl)
Valproic acid modulates collagen architecture in the postoperative conjunctival scar.