IQSEC3 Polyclonal antibody

IQSEC3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 22411-1-AP

Synonyms

IQ motif and Sec7 domain 3, IQSEC3, KIAA1110

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Validation Data Gallery

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  WB analysis using 22411-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 22411-1-AP (IQSEC3 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:16000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

22411-1-AP targets IQSEC3 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: IQSEC3 fusion protein Ag18117
• Full Name: IQ motif and Sec7 domain 3
• Calculated Molecular Weight: 1182 aa, 128 kDa
• Observed Molecular Weight: 128 kDa
• GenBank Accession Number: BC024764
• Gene Symbol: IQSEC3
• Gene ID (NCBI): 440073
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

IQSEC3, a gephyrin-binding GABAergic (gamma-aminobutyric acidergic) synapse-specific guanine nucleotide exchange factor, is expressed specifically in the adult brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. IQSEC3 was recently reported to regulate activity-dependent GABAergic synapse maturation,