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IL-17B Polyclonal antibody, PBS Only

IL-17B Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 24495-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using IL-17B Polyclonal antibody (24495-1-AP)

    WB analysis using 24495-1-AP (same clone as 24495-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24495-1-AP (IL-17B antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24495-1-PBS in a different storage buffer formulation.

Product Information

24495-1-PBS targets IL-17B in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen IL-17B fusion protein Ag21453
Full Name interleukin 17B
Calculated Molecular Weight 180 aa, 20 kDa
Observed Molecular Weight24 kDa
GenBank Accession NumberBC113925
Gene Symbol IL-17B
Gene ID (NCBI) 27190
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The interleukin (IL)-17 superfamily, a relatively new family of cytokines, consists of six ligands (from IL-17A to IL-17F), which bind to five receptor subtypes (from IL-17RA to IL-17RE) and induce downstream signaling. IL-17B was originally described as increased during intestinal inflammation. Moreover, it stimulates TNF-α and IL-1β production by the human monocytic leukemia THP-1 cells and promotes neutrophil migration upon intraperitoneal administration, suggesting a pro-inflammatory role. More recent findings strongly suggest a role for the IL-17B/IL-17RB pathway in tumorigenesis.