IHCeasy ATF4 Ready-To-Use IHC Kit
ATF4 Ready-to-use reagent kit for IHC.
Human, Mouse, Rat
Cat no : KHC1543
ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB
KHC1543 is a ready-to-use IHC kit for staining of ATF4. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.
|IHCeasy ATF4 Ready-To-Use IHC Kit
|Primary antibody type
|Secondary antibody type
|Human, Mouse, Rat
|Antigen Retrieval Buffer
|100 mL ×2
|Chromogen Component A
|Chromogen Component B
|Counter Staining Reagent
ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. ATF4 can bind DNA as a homodimer and as a heterodimer. ATF4 is ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.
|All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt.
|ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB