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FLNC Polyclonal antibody, PBS Only

FLNC Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28492-1-PBS

Synonyms

FLN2, FilaminC, Filamin C, Filamin 2, ABPL

Validation Data Gallery

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  • Western Blot (WB) analysis of SGC-7901 cells using FLNC Polyclonal antibody (28492-1-AP)

    WB analysis of SGC-7901 using 28492-1-AP (same clone as 28492-1-PBS)

    SGC-7901 cells were subjected to SDS PAGE followed by western blot with 28492-1-AP (filamin-c antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28492-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon using FLNC Polyclonal antibody (28492-1-AP)

    IHC staining of human colon using 28492-1-AP (same clone as 28492-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon slide using 28492-1-AP (FLNC antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28492-1-PBS in a different storage buffer formulation.

Product Information

28492-1-PBS targets FLNC in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FLNC fusion protein Ag29328
Full Name filamin C, gamma (actin binding protein 280)
Calculated Molecular Weight 291 kDa
Observed Molecular Weight 280-300 kDa
GenBank Accession NumberNM_001458
Gene Symbol FLNC
Gene ID (NCBI) 2318
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Filamin C (FLNC; also known as γ-FLN; ABP-L; FLN2), a muscle-specific filamin and a large actin-cross-linking protein. Human filamins are ~280 kDa homodimers, each monomer consisting of an N-terminal actin-binding domain followed by 24 immunoglobulin (Ig)-like domains (d1 to d24), the last of which mediates dimerization. FLNC is specifically expressed in cardiomyocytes and skeletal myocytes and is involved in the maintenance of structural integrity. High filamin C associated with better prognosis of prostate cancer, leukemia and breast cancer patients. ( PMID: 25577646, PMID: 30867563, PMID: 31131323)