DYRK1B Polyclonal antibody, PBS Only

DYRK1B Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 12240-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis of mouse testis using 12240-1-AP (same clone as 12240-1-PBS)

  mouse testis tissue were subjected to SDS PAGE followed by western blot with 12240-1-AP (DYRK1B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse skeletal muscle using 12240-1-AP (same clone as 12240-1-PBS)

  mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12240-1-AP (DYRK1B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human colon using 12240-1-AP (same clone as 12240-1-PBS)

  human colon tissue were subjected to SDS PAGE followed by western blot with 12240-1-AP (DYRK1B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human heart using 12240-1-AP (same clone as 12240-1-PBS)

  human heart tissue were subjected to SDS PAGE followed by western blot with 12240-1-AP (DYRK1B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12240-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 12240-1-AP (same clone as 12240-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 12240-1-AP (DYRK1B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12240-1-PBS in a different storage buffer formulation.

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Product Information

12240-1-PBS targets DYRK1B in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: DYRK1B fusion protein Ag2883
• Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
• Calculated Molecular Weight: 629 aa, 69 kDa
• Observed Molecular Weight: 57 kDa
• GenBank Accession Number: BC018751
• Gene Symbol: DYRK1B
• Gene ID (NCBI): 9149
• RRID: AB_2093803
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

DYRK1B(dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B) is also named as MIRK. It is a member of the dyrk/minibrain family of serine/threonine kinases that mediate the transition from growth to differentiation in lower eukaryotes and mammals(PMID:15546868). DYRK1B functions as a transcriptional coactivator that is activated by co-expressed MKK3, a MAP kinase that also can activate p38 MAP kinase(PMID:14500717). The DYRK1B splice variants found in each muscle tissue exhibit approximate molecular weights of 70 and 75 kDa(PMID:12902328). It has 3 isoforms produced by alternative splicing of the molecular weight of 65-69 kDa.