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  • KD/KO Validated

DYNLT1 Polyclonal antibody

DYNLT1 Polyclonal Antibody for WB, IP, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 11954-1-AP


CW 1, DYNLT1, Protein CW 1, TCTEL1, tctex 1, TCTEX1

Tested Applications

Positive WB detected inhuman brain tissue, human heart tissue, Sp2/0 cells
Positive IP detected inmouse skeletal muscle tissue
Positive IHC detected inhuman pancreas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:300-1:600
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11954-1-AP targets DYNLT1 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DYNLT1 fusion protein Ag2557
Full Name dynein, light chain, Tctex-type 1
Calculated Molecular Weight 113 aa, 12 kDa
Observed Molecular Weight 12 kDa
GenBank Accession NumberBC029412
Gene Symbol DYNLT1
Gene ID (NCBI) 6993
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

DYNLT (or Tctex-1) was originally described as a light chain component of the dynein motor complex. Tctex-1 also has several dynein-independent functions, including roles in G protein signaling activation and neuronal growth. Tctex-1 is selectively enriched in proliferating neural progenitors of both embryonic and adult brains. Genetic knockdown of Tctex-1 in radial precursors promoted neurogenesis, indicating its implication in regulation of cortical neurogenesis. (Pubmed: 19448628)


Product Specific Protocols
WB protocol for DYNLT1 antibody 11954-1-APDownload protocol
IHC protocol for DYNLT1 antibody 11954-1-APDownload protocol
IF protocol for DYNLT1 antibody 11954-1-APDownload protocol
IP protocol for DYNLT1 antibody 11954-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Neurosci

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.

Authors - Gauthier-Fisher Andrée A
  • KD Validated

Cell Res

Dlic1 deficiency impairs ciliogenesis of photoreceptors by destabilizing dynein.

Authors - Kong Shanshan S

J Cell Biol

Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.

Authors - Hironori Inaba
  • KD Validated

Cancers (Basel)

Dynein Light Chain Protein Tctex1: A Novel Prognostic Marker and Molecular Mediator in Glioblastoma.

Authors - Claudia Alexandra Dumitru

Biochem Pharmacol

Cannabinoid receptor-2 expression modulates Gβ1γ2 protein interaction with the activator of G protein signalling 2/dynein light chain protein Tctex-1.

Authors - Marina Nagler

J Cell Physiol

Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.

Authors - Ola Z Ismail
  • KD Validated