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DCC-Specific Monoclonal antibody, PBS Only

DCC-Specific Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2G4G4

Cat no : 67203-1-PBS

Synonyms

Colorectal cancer suppressor, CRC18, CRCR1, DCC, DCC-Specific, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse brain tissue using DCC-Specific Monoclonal antibody (67203-1-Ig)

    WB analysis of mouse brain using 67203-1-Ig (same clone as 67203-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 67203-1-Ig (DCC-Specific antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67203-1-PBS in a different storage buffer formulation.

Product Information

67203-1-PBS targets DCC-Specific in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Reactivity Human, Mouse
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen DCC-Specific fusion protein Ag20569
Full Name deleted in colorectal carcinoma
Calculated Molecular Weight 1447 aa, 158 kDa
Observed Molecular Weight 180 kDa
GenBank Accession NumberNM_005215
Gene Symbol DCC
Gene ID (NCBI) 1630
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC plays a key role in the developing nervous system. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).