Collagen Type XI Polyclonal antibody

Collagen Type XI Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF, IHC, ELISA

Conjugate

Unconjugated

Cat no : 21841-1-AP

Synonyms

CO11A1, COL11A1, COLL6, Collagen alpha 1(XI) chain, Collagen Type XI, collagen, type XI, alpha 1, STL2



Tested Applications

Positive IHC detected inhuman placenta tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

21841-1-AP targets Collagen Type XI in IF, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Collagen Type XI fusion protein Ag16509
Full Name collagen, type XI, alpha 1
Calculated Molecular Weight 1818 aa, 182 kDa
GenBank Accession NumberBC117697
Gene Symbol COL11A1
Gene ID (NCBI) 1301
RRIDAB_2918074
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

COL11A1 is an important component of collagen XI and is considered to play an important role in a variety of connective tissue diseases. Type XI collagen is widely distributed in tissues including cartilage, bone, and muscle, and its hereditary absence in Marshall's syndrome, Stickler's syndrome, fibrochondrogenesis, and nonsyndromic hearing loss deafness, autosomal dominant 37 leads to facial and eye abnormalities, hearing loss, and joint problems. The COL11A1 expression was significantly correlated with the degree of immune infiltration and the expression of a variety of immune cell markers in tumor tissue. (PMID: 36160004 33610546)

Protocols

Product Specific Protocols
IHC protocol for Collagen Type XI antibody 21841-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIF

Transl Oncol

Multiregion single cell analysis reveals a novel subtype of cancer-associated fibroblasts located in the hypoxic tumor microenvironment in colorectal cancer

Authors - Nanxin Zheng
humanIHC

J Orthop Res

Increased Wnt5a/ROR2 signaling is associated with chondrogenesis in meniscal degeneration

Authors - Yusuke Inoue
humanIHC,IF

BMC Med Genomics

Analysis of cancer-associated fibroblasts related genes identifies COL11A1 associated with lung adenocarcinoma prognosis

Authors - Haosheng Zheng
humanIHC

Front Immunol

COL11A1 as an novel biomarker for breast cancer with machine learning and immunohistochemistry validation

Authors - Wenjie Shi
humanIHC,IF

Oncogene

Single-cell landscape of undifferentiated pleomorphic sarcoma

Authors - Yifei Lu