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Cathepsin C Polyclonal antibody, PBS Only

Cathepsin C Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 30790-1-PBS

Synonyms

CTSC, CPPI

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Cathepsin C Polyclonal antibody (30790-1-AP)

    WB analysis using 30790-1-AP (same clone as 30790-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30790-1-AP (Cathepsin C antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30790-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human skin cancer tissue using Cathepsin C Polyclonal antibody (30790-1-AP)

    IHC staining of human skin cancer using 30790-1-AP (same clone as 30790-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 30790-1-AP (Cathepsin C antibody) at dilution of 1:100 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30790-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U2OS cells using Cathepsin C Polyclonal antibody (30790-1-AP)

    IF Staining of U2OS using 30790-1-AP (same clone as 30790-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed U2OS cells using Cathepsin C antibody (30790-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 30790-1-PBS in a different storage buffer formulation.

Product Information

30790-1-PBS targets Cathepsin C in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Cathepsin C fusion protein Ag32420
Full Name cathepsin C
Calculated Molecular Weight52 kDa
Observed Molecular Weight100 kDa
GenBank Accession NumberNM_001814
Gene Symbol Cathepsin C
Gene ID (NCBI) 1075
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Cathepsin C, also known as DPP-I. It is expected to be located in lysosome and highly expressed in lung, kidney and placenta (PMID: 9092576). This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. The calculated molecular weight of Cathepsin C is 51 kDa. The 23-kDa band may be a subunit of the protein monomer, while a 100-kda band is a dimer form (PMID: 26884336, 31557781).