CoraLite®555-conjugated CDC6 Monoclonal antibody
CDC6 Monoclonal Antibody for
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat
Applications
Conjugate
CoraLite®555 Fluorescent Dye
CloneNo.
6F12D2
Cat no : CL555-66021
Synonyms
Validation Data Gallery
Product Information
CL555-66021 targets CDC6 in applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CDC6 fusion protein Ag17958 |
| Full Name | cell division cycle 6 homolog (S. cerevisiae) |
| Calculated Molecular Weight | 560 aa, 63 kDa |
| Observed Molecular Weight | 65 kDa |
| GenBank Accession Number | BC025232 |
| Gene Symbol | CDC6 |
| Gene ID (NCBI) | 990 |
| Conjugate | CoraLite®555 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 557 nm / 570 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
CDC6, also named as CDC18L and HsCDC18, belongs to the CDC6/cdc18 family. It is involved in the initiation of DNA replication and functions as a regulator at the early steps of DNA replication. It also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5). MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human CDC6.
