FcZero-rAb™ PE Anti-Mouse CD98/SLC3A2 Rabbit Recombinant Antibody

CD98/SLC3A2 FcZero-rAb^TM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Conjugate

PE Fluorescent Dye

CloneNo.

241247F1

Cat no : PE-FcA98128

Synonyms

Mdu1, CD98, Amino acid transporter heavy chain SLC3A2, 4F2hc, 4F2 cell-surface antigen heavy chain

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Validation Data Gallery

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  FC experiment of mouse splenocytes using PE-FcA98128

  1x10^6 mouse splenocytes were surface stained with 0.25 ug PE Anti-Mouse CD98/SLC3A2 Rabbit Recombinant Antibody (PE-FcA98128, Clone: 241247F1), or 0.25 ug PE Rabbit IgG Isotype Control Recombinant Antibody (PE-FcA98136, Clone: 240953C9). Cells were not fixed.

• 

  FC experiment of mouse splenocytes using PE-FcA98128

  1x10^6 mouse splenocytes were surface stained with 0.25 ug PE Anti-Mouse CD98/SLC3A2 Rabbit Recombinant Antibody (PE-FcA98128, Clone: 241247F1) (red), or 0.25 ug PE Rabbit IgG Isotype Control Recombinant Antibody (PE-FcA98136, Clone: 240953C9) (blue). Cells were not fixed.

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Tested Applications

• Positive FC detected in: mouse splenocytes

Recommended dilution

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

PE-FcA98128 targets CD98/SLC3A2 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
• Calculated Molecular Weight: 58 kDa
• GenBank Accession Number: NM_008577.4
• Gene Symbol: CD98/SLC3A2
• Gene ID (NCBI): 17254
• Conjugate: PE Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 496 nm, 565 nm / 578 nm
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS with 0.09% sodium azide and 0.5% BSA.
• Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Background Information

CD98 is a cell-surface heterodimer consisting of a heavy chain (CD98hc) and a light chain. CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). This protein has 4 isoforms with the molecular mass of 58-71 kDa and can be detected 85-94 kDa due to glycosylation. The glycosylated CD98hc can links to a non-glycosylated light chain (~40 kDa) via a disulfide bond to form a heterodimeric CD98 antigen with molecular mass of 120-130 kDa (PMID: 14770309).