|Positive FC detected in||mouse splenocytes|
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.|
|Sample-dependent, check data in validation data gallery|
FITC-65060 targets CD3ε in FC applications and shows reactivity with Mouse samples.
|Host / Isotype||Hamster / IgG|
|Immunogen||H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone BM10-37|
|Full Name||CD3 antigen, epsilon polypeptide|
|GenBank accession number||BC098236|
|Gene ID (NCBI)||12501|
|Conjugate||FITC Fluorescent Dye|
|Excitation/Emission maxima wavelengths||498 nm / 526 nm|
|Purification Method||Affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide.|
|Storage Conditions||Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.|
CD3 is a multimeric protein associated with the T-cell receptor (TCR) to form a complex involved in antigen recognition and signal transduction (PMID: 15885124). CD3 is composed of CD3γ, δ, ε, and ζ chains (PMID: 1826255). It is expressed by thymocytes in a developmentally regulated manner, T cells, and some NK cells (PMID: 3289580). The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction (PMID: 11985657).
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