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Mouse CD200R1 Recombinant antibody, PBS Only

CD200R1 Uni-rAbTM Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

240979B6

Cat no : 83889-4-PBS

Synonyms

OX2R, Mox2r, CD200R, CD200 receptor 1, 240979B6

Validation Data Gallery

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  • Western Blot (WB) analysis of RAW 264.7 cells using CD200R1 Recombinant antibody (83889-4-RR)

    WB analysis of RAW 264.7 using 83889-4-RR (same clone as 83889-4-PBS)

    RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 83889-4-RR (CD200R1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83889-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83889-4-RR

    Affinity and Kinetic Characterization of 83889-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83889-4-RR against Mouse CD200R1 were performed. The affinity constant is 4.26 nM.

Product Information

The immunogen of 83889-4-PBS is CD200R1 Fusion Protein expressed in E. coli.

Tested Reactivity mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Fusion Protein
Full Name CD200 receptor 1
Calculated Molecular Weight36 kDa
Observed Molecular Weight36 kDa
GenBank Accession NumberNM_021325.3
Gene Symbol Cd200r1
Gene ID (NCBI) 57781
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Cell surface glycoprotein CD200 receptor 1 (CD200R1) is also called CD200R, CRTR2, MOX2R, and OX2R, and belongs to the CD200R family. CD200R1 is an inhibitory receptor for the CD200/OX2 cell surface glycoprotein. CD200R1 is highly glycosylated, containing ten potential N-glycosylation sites (PMID: 15187158). CD200R1 limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. As an immune inhibitory molecule, CD200R1 binds to CD200, ultimately leading to the inhibition of classical activation of macrophages and microglia (PMID: 24588829).