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BRCA2 Polyclonal antibody

BRCA2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 19791-1-AP

Synonyms

BRCA2, BRCC2, breast cancer 2, early onset, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

19791-1-AP targets BRCA2 in WB, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name breast cancer 2, early onset
Calculated molecular weight 384 kDa
GenBank accession numberNM_000059
Gene symbol BRCA2
Gene ID (NCBI) 675
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. BRCA2 may participate in S phase checkpoint activation. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) which also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).

Protocols

Product Specific Protocols
WB protocol for BRCA2 antibody 19791-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

J Hematol Oncol

SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.

Authors - Ming Li
humanWB

Ann Transl Med

miR-1245a promotes the proliferation and invasion of colon adenocarcinoma by targeting BRCA2.

Authors - Zihao Pan
humanWB

Cell Death Dis

FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair.

Authors - Shu-Ping Wang
humanWB,IHC

Cancer Biol Ther

A novel BRCA2 mutation in prostate cancer sensitive to combined radiotherapy and androgen deprivation therapy.

Authors - Qiuli Liu
humanWB

Hum Cell

Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.

Authors - Xing Ren
humanIHC

Virology

DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas.

Authors - Andrew J Holcomb