- Featured Product
- KD/KO Validated
Alpha Actinin Polyclonal antibody, PBS Only
Alpha Actinin Polyclonal Antibody for WB, IHC, IF-P, FC (Intra), Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, IHC, IF-P, FC (Intra), Indirect ELISA
Conjugate
Unconjugated
Cat no : 11313-2-PBS
Synonyms
Validation Data Gallery
Product Information
11313-2-PBS targets Alpha Actinin in WB, IHC, IF-P, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Alpha Actinin fusion protein Ag1859 |
Full Name | actinin, alpha 1 |
Calculated Molecular Weight | 103 kDa |
Observed Molecular Weight | 100-105 kDa |
GenBank Accession Number | BC015766 |
Gene Symbol | Alpha Actinin |
Gene ID (NCBI) | 87 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Alpha Actinins are highly conserved actin-binding proteins that form antiparallel homodimers with the actin-binding domains on each end of the molecule, allowing crosslinking of actin molecules. There are four alpha actinin isoforms identified: two ubiquitously expressed cytoskeletal isoforms (ACTN1 and ACTN4) and two striated muscle-specific sarcomeric isoforms (ACTN2 and ACTN3). ACTN1 is also alternatively spliced to form smooth muscle or brain specific isoforms. This antibody recognize endogenous ACTN1, while it may cross-react with ACTN2 and ACTN4.