APOBEC2 antibody (pAb)
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB
Cat No : 39985,39986 39985
Synonyms
Validation Data Gallery
Product Information
| Tested Applications |
WB
Applications Validated by Active Motif: WB: 1:500 - 1:2,000 dilution |
| Tested Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This APOBEC2 antibody was raised against a peptide derived from the N-terminal region of human APOBEC2. |
| Full Name | APOBEC2 antibody (pAb) |
| Synonyms | APOBEC2, Apolipoprotein B mRNA-editing enzyme catalytic subunit 2, TNF-a, NFκB, inflammation, cytidine deaminase, DNA methylation, deaminates 5-methylcytosine, Mbd4, antibody, polyclonal, sample |
| Molecular weight | 35 kDa |
| GenBank accession number | NP_006780 |
| RRID | AB_2793418 |
| Purification Method | Affinity Purified |
| Buffer | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
Background Information
APOBEC2 (Apolipoprotein B mRNA-editing enzyme catalytic subunit 2) is part of a family of enzymes that edit nucleic acids, possibly changing cytosine to uracil. APOBEC2 expression is regulated by TNF-a via NFkB activation and this suggests a possible role for APOBEC2 in the pathophysiology of hepatic inflammation. APOBEC2 has a low intrinsic cytidine deaminase activity and is also involved in DNA demethylation. APOBEC2 deaminates 5-methylcytosine, followed by base excision repair by Mbd4.