Angiotensinogen Monoclonal antibody

Angiotensinogen Monoclonal Antibody for ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

Conjugate

Unconjugated

CloneNo.

2H2A10

Cat no : 60126-1-Ig

Synonyms

AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, Serpin A8, SERPINA8



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

60126-1-Ig targets Angiotensinogen in applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen Angiotensinogen fusion protein Ag2632
Full Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Calculated molecular weight 485 aa, 53 kDa
Observed molecular weight 52 kDa
GenBank accession numberBC011519
Gene symbol AGT
Gene ID (NCBI) 183
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Publications

SpeciesApplicationTitle
human

Cells

Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation-Causing Autosomal Recessive Renal Tubular Dysgenesis.

Authors - Min-Hua Tseng