ACVRL1 Polyclonal antibody, PBS Only

ACVRL1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 14745-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis of human placenta using 14745-1-AP (same clone as 14745-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 14745-1-AP (ACVRL1 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human placenta using 14745-1-AP (same clone as 14745-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 14745-1-AP (ACVRL1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

• 

  IP experiment of Jurkat using 14745-1-AP (same clone as 14745-1-PBS)

  IP result of anti-ACVRL1 (IP:14745-1-AP, 4ug; Detection:14745-1-AP 1:300) with Jurkat cells lysate 2400ug. This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human heart using 14745-1-AP (same clone as 14745-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 14745-1-AP (ACVRL1 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lymphoma using 14745-1-AP (same clone as 14745-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lymphoma using 14745-1-AP (ACVRL1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lymphoma using 14745-1-AP (same clone as 14745-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lymphoma using 14745-1-AP (ACVRL1 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

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Product Information

14745-1-PBS targets ACVRL1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: ACVRL1 fusion protein Ag6449
• Full Name: activin A receptor type II-like 1
• Calculated Molecular Weight: 56 kDa
• Observed Molecular Weight: 63 kDa
• GenBank Accession Number: BC042637
• Gene Symbol: ACVRL1
• Gene ID (NCBI): 94
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.