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  • ERK MAPK pathway
Activation Inhibition Translocation Phosphorylation Ubiquitin Ub P Cell survival Degradation Translationof mRNAs cAMP ATP Integrin IonChannels GPCR RTK FAK PKC PKA PAK RAC RACK1 ERK1/2 ERK1/2 AC RPS6 CREB Raptor TRIM24 BAD LKB1 DAPK DUSP1 DUSP2 DUSP5 DUSP9 GSK3 EIF4B MEK1/2 GAB1/2 GRB2 GRB2 SOS SOS RAS RAF1 BRAF ARAF c-FOS JUN MSK CREB ATF1 Histone H3 c-MYC ELK HIF1 STAT RAS Gβ Gγ Gα Gα RPS6KA RPS6KA Bim Bim GTP GTP GDP GDP MNK1/2 EIF4G EIF4E EIF4A EIF3 Ub Ub Ub P P P P P P P P P P P P P P P P P P P P P P P P P P P P P Cytoplasm Nucleus

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