• Phare
  • Validé par KD/KO

Anticorps Polyclonal de lapin anti-ZNF746

ZNF746 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF, IHC, ELISA

Conjugaison

Non conjugué

N° de cat : 24543-1-AP

Synonymes

PARIS, zinc finger protein 746, ZNF746



Applications testées

Résultats positifs en WBcellules HEK-293, cellules HEK-293T

Dilution recommandée

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

24543-1-AP cible ZNF746 dans les applications de WB, IF, IHC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Réactivité citéerat, Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène ZNF746 Protéine recombinante Ag21566
Nom complet zinc finger protein 746
Masse moléculaire calculée 644 aa, 69 kDa
Poids moléculaire observé 85-95 kDa
Numéro d’acquisition GenBankBC068505
Symbole du gène ZNF746
Identification du gène (NCBI) 155061
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN (PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).

Protocole

Product Specific Protocols
WB protocol for ZNF746 antibody 24543-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Neuron

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.

Authors - Nikhil Panicker
  • KO Validated
human,mouseWB

Sci Adv

Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.

Authors - Sheila K Pirooznia
mouseWB

Brain

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.

Authors - Saurav Brahmachari
human,mouseWB,IF

Brain

Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration.

Authors - Hyojung Kim
mouseWB

Front Aging Neurosci

Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice

Authors - Hyojung Kim
human,mouseWB,IHC

Biochem Biophys Res Commun

ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.

Authors - Hanna Kim
  • KO Validated