- Phare
- Validé par KD/KO
Anticorps Polyclonal de lapin anti-TREX1
TREX1 Polyclonal Antibody for WB, IP, ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain
Applications
WB, IP, IF, ELISA
Conjugaison
Non conjugué
N° de cat : 24876-1-AP
Synonymes
Galerie de données de validation
Applications testées
| Résultats positifs en WB | cellules HeLa, cellules HepG2 |
| Résultats positifs en IP | cellules HeLa |
Dilution recommandée
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:3000 |
| Immunoprécipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Applications publiées
| KD/KO | See 1 publications below |
| WB | See 3 publications below |
| IF | See 1 publications below |
Informations sur le produit
24876-1-AP cible TREX1 dans les applications de WB, IP, IF, ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Réactivité citée | Humain |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Polyclonal |
| Type | Anticorps |
| Immunogène | TREX1 Protéine recombinante Ag18325 |
| Nom complet | three prime repair exonuclease 1 |
| Masse moléculaire calculée | 369 aa, 39 kDa |
| Poids moléculaire observé | 32-39 kDa |
| Numéro d’acquisition GenBank | BC023630 |
| Symbole du gène | TREX1 |
| Identification du gène (NCBI) | 11277 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par affinité contre l'antigène |
| Tampon de stockage | PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3 |
| Conditions de stockage | Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
TREX1 (three prime repair exonuclease 1), also known as trophoblast expressed 1, CRV, AGS1, AGS5, DRN3, HERNS or DNase III, is a member of the exonuclease superfamily and belongs to the TREX family. TREX1 may play a role in DNA repair. TREX1 is expressed in thymus, spleen, liver, brain, heart, small intestine and colon. Mutations or defects in the gene encoding TREX1 have been associated with a variety of diseases, including systemic lupus erythematosus, chilblain lupus (CHBL), Aicardi-Goutieres syndrome type 1 (AGS1) and type 5 (AGS5).
Protocole
| Product Specific Protocols | |
|---|---|
| WB protocol for TREX1 antibody 24876-1-AP | Download protocol |
| IP protocol for TREX1 antibody 24876-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
J Neuropathol Exp Neurol Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation. | ||
bioRxiv Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection
| ||
Cell Host Microbe Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection | ||
Cell Rep Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition |
Avis
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
FH Chantal (Verified Customer) (10-04-2022) | reconignises the specific band, validated by KO of TREX1. A little bit of background. the signal is weak at 1:1000 dilution, better at 1:500. Works on human and mouse cell lines.
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