Anticorps Polyclonal de lapin anti-TMEM176B

TMEM176B Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications

2

N° de cat : 19825-1-AP

Synonymes

LR8, Protein LR8, TMEM176B, transmembrane protein 176B

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Galerie de données de validation

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  WB analysis of A549 using 19825-1-AP

  A549 cells were subjected to SDS PAGE followed by western blot with 19825-1-AP (TMEM176B Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of A549 using 19825-1-AP

  A549 cells were subjected to SDS PAGE followed by western blot with 19825-1-AP (TMEM176B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of human placenta using 19825-1-AP

  human placenta tissue were subjected to SDS PAGE followed by western blot with 19825-1-AP (TMEM176B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules A549, tissu placentaire humain

Dilution recommandée

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below

Informations sur le produit

19825-1-AP cible TMEM176B dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TMEM176B Protéine recombinante Ag13918
• Nom complet: transmembrane protein 176B
• Masse moléculaire calculée: 270 aa, 29 kDa
• Poids moléculaire observé: 31 kDa, 23 kDa
• Numéro d’acquisition GenBank: BC004358
• Symbole du gène: TMEM176B
• Identification du gène (NCBI): 28959
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

TMEM176B (also known as LR8) is a transmembrane protein belongs to the MS4A family of proteins. It may play a role in the process of maturation of dendritic cells. TMEM176B was first discovered in human lung fibroblasts and is associated with human small cell lung carcinoma. Studies suggest that TMEM176B might be involved in cancer and might serve as targets for antiangiogenic therapy of cancer patients (PMID: 24602018, 22244448). There are two isoforms produced by alternative splicing.

Publications

Species	Application	Title
human	WB	Front Genet; Comprehensive Analysis of Expression and Prognostic Value of MS4As in Glioma.; Authors - Yingying Zeng
		Cancer Cell; Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation.; Authors - Mercedes Segovia