Anticorps Polyclonal de lapin anti-STMN3

• Phare
• Validé par KD/KO

STMN3 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF, IHC, ELISA

Conjugaison

Non conjugué

Publications

7

N° de cat : 11311-1-AP

Synonymes

SCG10 like protein, SCLIP, Stathmin 3, stathmin like 3, STMN3

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Galerie de données de validation

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  WB analysis using 11311-1-AP

  SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 11311-1-AP (STMN3 antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules SH-SY5Y,

Dilution recommandée

• Western Blot (WB): WB : 1:5000-1:20000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 1 publications below
• WB: See 7 publications below
• IHC: See 1 publications below
• IF: See 1 publications below

Informations sur le produit

11311-1-AP cible STMN3 dans les applications de WB, IF, IHC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: STMN3 Protéine recombinante Ag1853
• Nom complet: stathmin-like 3
• Masse moléculaire calculée: 21 kDa
• Poids moléculaire observé: 21-25 kDa
• Numéro d’acquisition GenBank: BC009381
• Symbole du gène: STMN3
• Identification du gène (NCBI): 50861
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Stathmin family phosphoproteins participate in the control of microtubule dynamics and have been proposed to be involved in the control of neuronal differentiation. Neuron specific Stathmin-3 (STMN3) is a novel STAT3 (signal transducer and activator of transcription 3) interacting protein. STAT3 is a key contributor to cancer cell migration and invasion. STMN3 exhibits microtubule-destabilizing activity, which is antagonized by STAT3. SCG10 is a widely studied and recognized neuronal differentiation marker, STMN3 is a SCG10-like protein (SCLIP) and is present from the earliest stages of hippocampal neuron differentiation in culture at vesicle-like structures following dynamic microtubules. RNAi mediated inhibition of this gene resulted in increased axonal branching.

Publications

Species	Application	Title
human	WB, IHC	Cancer Res; Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer.; Authors - Stephan Singer
human	WB	Cancer Res; RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome.; Authors - Nicholas Rooney
mouse	WB,IF	Elife; HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration.; Authors - Alicia Tapias
human	WB	Mol Cancer Ther; PMID: 23543364; Authors - Xie Xuemei X ; KD Validated
mouse	WB	J Biol Chem; The Stathmin-2 membrane targeting domain is required for axon protection and regulated degradation by DLK signaling; Authors - Emma J C Thornburg-Suresh
	WB	BMC Cell Biol; CiteAb: a searchable antibody database that ranks antibodies by the number of times they have been cited.; Authors - Matthew A Helsby