Anticorps Polyclonal de lapin anti-ZnT6

• Phare
• Validé par KD/KO

ZnT6 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications

7

N° de cat : 13526-1-AP

Synonymes

MST103, MSTP103, SLC30A6, Zinc transporter 6, ZnT 6, ZNT6

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Galerie de données de validation

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  WB analysis of A375 using 13526-1-AP

  A375 cells were subjected to SDS PAGE followed by western blot with 13526-1-AP (ZnT6 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  WB analysis of K-562 using 13526-1-AP

  K-562 cells were subjected to SDS PAGE followed by western blot with 13526-1-AP (ZnT6 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules A375, cellules K-562

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2400

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 1 publications below
• WB: See 7 publications below

Informations sur le produit

13526-1-AP cible ZnT6 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain, poulet, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ZnT6 Protéine recombinante Ag4403
• Nom complet: solute carrier family 30 (zinc transporter), member 6
• Masse moléculaire calculée: 460 aa, 50 kDa
• Poids moléculaire observé: 51 kDa
• Numéro d’acquisition GenBank: BC032525
• Symbole du gène: ZnT6
• Identification du gène (NCBI): 55676
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

ZnT6 (encoded by SLC30A6) is a member of zinc transporters. ZnT6 is localized on the membrane of the Golgi apparatus as well as cytoplasmic vesicles. It may function in transporting the cytoplasmic zinc into the Golgi apparatus as well as the vesicular compartment. Altered expression of ZnT6 may correlate to neural diseases including Alzheimer's disease. Several isoforms of ZnT6 exist due to the alternative splicing, with MW around 48-56 kDa.

Publications

Species	Application	Title
mouse	WB	Acta Neuropathol Commun; Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder.; Authors - Alexandra Grubman
human	WB	J Biol Chem; Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway.; Authors - Fukunaka Ayako A
mouse	WB	Metallomics; Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?; Authors - Alexandra Grubman
chicken	WB	J Biol Chem; Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation.; Authors - Eisuke Suzuki ; KO Validated
Yellow catfish	WB	Biochim Biophys Acta Gene Regul Mech; Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.; Authors - Chang-Chun Song
human, mouse	WB	J Neurosci Res; Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.; Authors - Masayuki Kaneko