Anticorps Polyclonal de lapin anti-NR1H2

• Phare
• Validé par KD/KO

NR1H2 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IP, IF, ELISA

Conjugaison

Non conjugué

Publications

9

N° de cat : 14278-1-AP

Synonymes

Liver X receptor beta, LXR b, LXRB, NER, NER I, NR1H2, Nuclear receptor NER, Oxysterols receptor LXR beta, RIP15, UNR

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Galerie de données de validation

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  WB analysis of mouse liver using 14278-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 14278-1-AP (NR1H2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Applications testées

Applications publiées

• KD/KO: See 2 publications below
• WB: See 9 publications below
• IF: See 1 publications below
• IP: See 1 publications below

Informations sur le produit

14278-1-AP cible NR1H2 dans les applications de WB, IP, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: NR1H2 Protéine recombinante Ag5635
• Nom complet: nuclear receptor subfamily 1, group H, member 2
• Masse moléculaire calculée: 51 kDa
• Poids moléculaire observé: 50 kDa, 40 kDa
• Numéro d’acquisition GenBank: BC047750
• Symbole du gène: NR1H2
• Identification du gène (NCBI): 7376
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Publications

Species	Application	Title
mouse	WB	Nat Immunol; Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27.; Authors - Heeju Ryu
mouse	WB	Br J Pharmacol; Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.; Authors - Chuanrui Ma
mouse	WB	Int J Cancer; Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production.; Authors - Xingzhe Ma ; KD Validated
mouse	WB	Sci Rep; Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice.; Authors - Qixue Wang
human	WB, IF	J Biol Chem; Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II.; Authors - Mengyang Liu
mouse	WB	Biochem J; Identification of interferon-γ as a new molecular target of liver X receptor.; Authors - Qixue Wang ; KD Validated