Anticorps Polyclonal de lapin anti-MCL1L-specific

MCL1L-specific Polyclonal Antibody for IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

IHC, ELISA

Conjugaison

Non conjugué

N° de cat : 15825-1-AP

Synonymes

EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM

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Galerie de données de validation

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  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human kidney using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human kidney using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human placenta using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human placenta using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human testis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human testis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human skin using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human skin using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human brain using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human brain using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human brain using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human brain using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human spleen using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human spleen using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human lung using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human lung using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human lung using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human ovary using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human ovary using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human ovary using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human ovary using 15825-1-AP (MCL1L-specific antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human breast cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human breast cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human cervical cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human cervical cancer using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human tonsillitis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human tonsillitis using 15825-1-AP

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 15825-1-AP (MCL1L-specific antibody at dilution of 1:50 (under 40x lens).

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Applications testées

• Résultats positifs en IHC: tissu splénique humain, tissu cérébral humain, tissu cutané humain, tissu d'amygdalite humain, tissu de cancer du col de l'utérus humain, tissu de cancer du sein humain, tissu ovarien humain, tissu placentaire humain, tissu pulmonaire humain, tissu rénal humain, tissu testiculaire humain; il est suggéré de démasquer l'antigène avec un tampon de TE buffer pH 9.0; (*) À défaut, 'le démasquage de l'antigène peut être 'effectué avec un tampon citrate pH 6,0.

Dilution recommandée

• Immunohistochimie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

15825-1-AP cible MCL1L-specific dans les applications de IHC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: myeloid cell leukemia sequence 1 (BCL2-related)
• Masse moléculaire calculée: 37 kDa
• Numéro d’acquisition GenBank: NM_182763
• Symbole du gène: MCL1
• Identification du gène (NCBI): 4170
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. This antibody is specific to MCL1L isoform.