Anticorps Polyclonal de lapin anti-VEGF Receptor 2

VEGF Receptor 2 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (1)

Applications

IHC, ELISA

Conjugaison

Non conjugué

Publications

1

N° de cat : 18975-1-AP

Synonymes

CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGF Receptor 2, VEGFR, VEGFR 2, VEGFR2

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Galerie de données de validation

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  IHC staining of human breast cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human breast cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 18975-1-AP (VEGF Receptor 2 antibody at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human placenta using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 18975-1-AP (VEGF Receptor 2 antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human placenta using 18975-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta using 18975-1-AP (VEGF Receptor 2 antibody) at dilution of 1:50 (under 40x lens).

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Applications testées

Applications publiées

• IHC: See 1 publications below

Informations sur le produit

18975-1-AP cible VEGF Receptor 2 dans les applications de IHC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: kinase insert domain receptor (a type III receptor tyrosine kinase)
• Masse moléculaire calculée: 152 kDa
• Numéro d’acquisition GenBank: NM_002253
• Symbole du gène: KDR
• Identification du gène (NCBI): 3791
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

Publications

Species	Application	Title
mouse	IHC	Kidney Int; TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.; Authors - Xu Chang C