Anticorps Recombinant de lapin anti-IL-23R

IL-23R Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

240989A12

N° de cat : 83918-3-PBS

Synonymes

Il23r, interleukin 23 receptor, IL 23R, IL 23 receptor, 240989A12

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Galerie de données de validation

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  WB analysis using 83918-3-RR (same clone as 83918-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83918-3-RR (IL23R antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83918-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 83918-3-RR

  Biolayer interferometry (BLl) kinetic assays of 83918-3-RR against Mouse IL-23R were performed. The affinity constant is 3.44 nM.

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Informations sur le produit

83918-3-PBS cible IL-23R dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: interleukin 23 receptor
• Masse moléculaire calculée: 73 kDa
• Poids moléculaire observé: 73 kDa
• Symbole du gène: Il23r
• Identification du gène (NCBI): 209590
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin-23 receptor (IL-23R) is a type I cytokine receptor that plays a critical role in immune responses and inflammation. It forms a receptor complex with IL-12Rβ1 and is activated by the cytokine IL-23, which is primarily produced by dendritic cells and activated macrophages (PMID: 39796684). The genetic and epigenetic interactions in the IL-23R/IL-17 axis are associated with elevated expression of IL-17 and inflammatory bowel disease (IBD) pathogenesis (PMID: 21672939).

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