Anticorps Polyclonal de lapin anti-ICAM5

ICAM5 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications

1

N° de cat : 12759-1-AP

Synonymes

ICAM 5, ICAM5, Telencephalin, TLCN, TLN

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Galerie de données de validation

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  WB analysis of mouse brain using 12759-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse brain using 12759-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 12759-1-AP (ICAM5 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below

Informations sur le produit

12759-1-AP cible ICAM5 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ICAM5 Protéine recombinante Ag3303
• Nom complet: intercellular adhesion molecule 5, telencephalin
• Masse moléculaire calculée: 924 aa, 97 kDa
• Poids moléculaire observé: 140 kDa
• Numéro d’acquisition GenBank: BC026338
• Symbole du gène: ICAM5
• Identification du gène (NCBI): 7087
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

ICAM-5, also known as telencephalin, is a type I integral membrane glycoprotein of the immunoglobulin superfamily. It is specifically expressed in the postnatal excitatory neuronal cell bodies, dendritic shafts, and dendritic filopodia of the telencephalon. ICAM-5 functions in both the immune and nervous systems. ICAM-5 strongly stimulates neurite outgrowth. It is cleaved by matrix metalloproteases upon activation of glutamate receptors or degraded through endocytosis resulting in increased spine maturation. The cleaved soluble fragment of ICAM-5 is immunosuppressive, which may be important in neuronal inflammatory diseases. (PMID: 10402269; 17682049; 25300135)

Publications

Species	Application	Title
human	WB	Oncotarget; Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein.; Authors - Yanxiao Zhang