- Phare
- Validé par KD/KO
Anticorps Polyclonal de lapin anti-GPSM2
GPSM2 Polyclonal Antibody for ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain et plus (1)
Applications
WB, IF, IHC, ELISA
Conjugaison
Non conjugué
N° de cat : 11608-2-AP
Synonymes
Galerie de données de validation
Applications testées
Applications publiées
| KD/KO | See 1 publications below |
| WB | See 3 publications below |
| IHC | See 1 publications below |
| IF | See 3 publications below |
Informations sur le produit
11608-2-AP cible GPSM2 dans les applications de WB, IF, IHC, ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Réactivité citée | Humain, souris |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Polyclonal |
| Type | Anticorps |
| Immunogène | GPSM2 Protéine recombinante Ag2167 |
| Nom complet | G-protein signaling modulator 2 (AGS3-like, C. elegans) |
| Masse moléculaire calculée | 75 kDa |
| Numéro d’acquisition GenBank | BC027732 |
| Symbole du gène | GPSM2 |
| Identification du gène (NCBI) | 29899 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par affinité contre l'antigène |
| Tampon de stockage | PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3 |
| Conditions de stockage | Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
GPSM2 belongs to a family of proteins that modulate activation of G proteins. GPSM2 assists in the exchange of guanine nucleotides, and allows extracellular signals to be transmitted to cells via cell surface, and ultimately plays a key role in the activation of G-proteins. Therefore, GPSM2 is a critical factor for the stability of cell division. Some recent studies have shown that GPSM2 messenger RNA (mRNA) is overexpressed and plays a positive role in the development of certain tumors, such as liver cancer, pancreatic cancer, breast cancer. It also plays a role in neuroblast division and in the development of normal hearing. Mutations in GPSM2 are associated with autosomal recessive nonsyndromic deafness (DFNB82), which is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss.
Publications
| Species | Application | Title |
|---|---|---|
Am J Hum Genet Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. | ||
Sci Rep Deletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochlea. | ||
Mol Biol Cell NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. | ||
Genes Chromosomes Cancer Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells.
| ||
