Anticorps Monoclonal anti-CXCL8/IL8

CXCL8/IL8 Monoclonal Antibody for ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

Publications(8)

CloneNo.

3D11D5

N° de cat : 60141-2-Ig

Synonymes

C X C motif chemokine 8, CXC chemokine ligand 8, CXCL 8, CXCL8, IL 8, IL8, Inteleukin 8, interleukin 8

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Galerie de données de validation

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Applications publiées

• WB: See 3 publications below
• IHC: See 3 publications below
• ELISA: See 1 publications below

Informations sur le produit

60141-2-Ig cible CXCL8/IL8 dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CXCL8/IL8 Protéine recombinante Ag10552
• Nom complet: interleukin 8
• Masse moléculaire calculée: 99 aa, 11 kDa
• Numéro d’acquisition GenBank: BC013615
• Symbole du gène: IL-8
• Identification du gène (NCBI): 3576
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. The human IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa).

Publications

Species	Application	Title
		Nat Commun; Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.; Authors - Hasini Jayatilaka
human	WB	Aging Cell; Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.; Authors - Qixia Xu
human	WB,IHC	Front Immunol; Ultraviolet B Inhibits IL-17A/TNF-α-Stimulated Activation of Human Dermal Fibroblasts by Decreasing the Expression of IL-17RA and IL-17RC on Fibroblasts.; Authors - Li Yin
human	IHC	PLoS One; Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate.; Authors - Ami Oizumi
human	IHC	Cancer Med; Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.; Authors - Sen Wang
		Placenta; Placental inflammation by HMGB1 activation of TLR4 at the syncytium.; Authors - Line H Tangerås

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