Anticorps Monoclonal anti-CCR6

CCR6 Monoclonal Antibody for IF-P

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

IF-P

Conjugaison

CoraLite®594 Fluorescent Dye

CloneNo.

1C11A9

N° de cat : CL594-66801

Synonymes

BN 1, C C chemokine receptor type 6, C C CKR 6, CC CKR 6, CCR 6, CCR6, CD196, Chemokine receptor like 3, CKR L3, CKR6, CKRL3, CMKBR6, DCR2, DRY 6, DRY6, G protein coupled receptor 29, GPR CY4, GPR29, GPRCY4, LARC receptor, STRL22

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Galerie de données de validation

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  IF Staining of human tonsillitis using CL594-66801

  Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 CCR6 antibody (CL594-66801, Clone: 1C11A9 ) at dilution of 1:200.

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  IF Staining of human tonsillitis using CL594-66801

  Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 CCR6 antibody (CL594-66801, Clone: 1C11A9 ) at dilution of 1:200.

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Applications testées

• Résultats positifs en IF-P: tissu d'amygdalite humain,

Dilution recommandée

• Immunofluorescence (IF)-P: IF-P : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

CL594-66801 cible CCR6 dans les applications de IF-P et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CCR6 Protéine recombinante Ag24195
• Nom complet: chemokine (C-C motif) receptor 6
• Masse moléculaire calculée: 42 kDa
• Numéro d’acquisition GenBank: BC037960
• Symbole du gène: CCR6
• Identification du gène (NCBI): 1235
• Conjugaison: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Conditions de stockage: Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CCR6, also known CD196, is a C-C chemokine receptor that belongs to family A of G protein-coupled receptor superfamily. It is expressed on most B cells, memory T cells, and some subsets of dendritic cells (PMID: 17057190). CCR6 is a receptor for the C-C type chemokine CCL20 (PMID: 9169459). The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells, effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis (PMID: 12948524). CCR6 polymorphism has been associated with rheumatoid arthritis susceptibility and CCR6 is involved in IL-17-driven autoimmunity in human diseases (PMID: 20453841).

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