Anticorps Polyclonal de lapin anti-androgen receptor
androgen receptor Polyclonal Antibody for ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain, porc, singe
Applications
WB, IF, IHC, ELISA
Conjugaison
Non conjugué
N° de cat : 22576-1-AP
Synonymes
Galerie de données de validation
Applications testées
Applications publiées
| WB | See 2 publications below |
| IHC | See 1 publications below |
| IF | See 1 publications below |
Informations sur le produit
22576-1-AP cible androgen receptor dans les applications de WB, IF, IHC, ELISA et montre une réactivité avec des échantillons Humain, porc, singe
| Réactivité | Humain, porc, singe |
| Réactivité citée | Humain |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Polyclonal |
| Type | Anticorps |
| Immunogène | androgen receptor Protéine recombinante Ag17385 |
| Nom complet | androgen receptor |
| Masse moléculaire calculée | 914 aa, 99 kDa |
| Poids moléculaire observé | 110 kDa |
| Numéro d’acquisition GenBank | BC132975 |
| Symbole du gène | AR |
| Identification du gène (NCBI) | 367 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par affinité contre l'antigène |
| Tampon de stockage | PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3 |
| Conditions de stockage | Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
Androgen receptor (AR) also konwn as Dihydrotestosterone receptor (DHTR), Nuclear receptor subfamily 3 group C member 4 (NR3C4).It is one of steriod hormoen receptors, which are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.Defects in AR are the cause of androgen insensitivity syndrome (AIS).Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1). In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS). PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.This antibody is a rabbit polyclonal antibody. It can specifically recognize the 110kd AR protein.
Publications
| Species | Application | Title |
|---|---|---|
Med Oncol α-Viniferin activates autophagic apoptosis and cell death by reducing glucocorticoid receptor expression in castration-resistant prostate cancer cells. | ||
Mol Med Rep HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain. |
Avis
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
FH Parmveer (Verified Customer) (12-02-2019) | Did not stain nuclear AR
 |
