Thyroid Hormone Receptor beta Polyklonaler Antikörper

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• KD/KO Validated

Thyroid Hormone Receptor beta Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus und mehr (1)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen(2)

Kat-Nr. : 21007-1-AP

Synonyme

c erbA 2, c erbA beta, ERBA BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB, THRB1, THRB2, Thyroid Hormone Receptor beta

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  WB analysis using 21007-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 21007-1-AP (Thyroid Hormone Receptor beta antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Maus-Retina-Gewebe, Maus-Augengewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 2 publications below
• IHC: See 1 publications below
• IF: See 1 publications below

Produktinformation

21007-1-AP bindet in WB, IHC, IF, ELISA Thyroid Hormone Receptor beta und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Thyroid Hormone Receptor beta fusion protein Ag15210
• Vollständiger Name: thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
• Berechnetes Molekulargewicht: 476 aa, 54 kDa
• Beobachtetes Molekulargewicht: 50 kDa
• GenBank-Zugangsnummer: BC106929
• Gene symbol: Thyroid Hormone Receptor beta
• Gene ID (NCBI): 7068
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Thyroid hormone receptor beta (THRB), also known as ERBA2, NR1A2, and THR1, belongs to the nuclear hormone receptor family and NR1 subfamily. THRB is a nuclear hormone receptor that can act as a repressor or activator of transcription. Moreover, THRB is also a high-affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. THRB is the most abundant THR isoform in the liver but is also expressed in other tissues and mediates the effects of THs on hepatic carbohydrate and lipid metabolism (PMID: 34884910).

Publikationen

Species	Application	Title
human,mouse	WB,IF	Theranostics; Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease; Authors - Yan-Hang Wang ; KD Validated
human	WB,IHC	Biomark Insights; The Prognostic Significance of TRs in Hepatocellular Carcinoma: Insights from TCGA and GEO Databases; Authors - Hao Zhou