TSPAN5 Polyklonaler Antikörper

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• KD/KO Validated

TSPAN5 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen

2

Kat-Nr. : 12122-1-AP

Synonyme

NET 4, NET4, Tetraspan NET 4, tetraspanin 5, TM4SF9, TSPAN 5, TSPAN5

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Galerie der Validierungsdaten

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  WB analysis of Jurkat using 12122-1-AP

  Jurkat cells were subjected to SDS PAGE followed by western blot with 12122-1-AP (TSPAN5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

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  WB analysis of Jurkat using 12122-1-AP

  WB result of TSPAN5 antibody (12122-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TSPAN5 transfected Jurkat cells.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Jurkat-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 2 publications below

Produktinformation

12122-1-AP bindet in WB, ELISA TSPAN5 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TSPAN5 fusion protein Ag2765
• Vollständiger Name: tetraspanin 5
• Berechnetes Molekulargewicht: 268 aa, 30 kDa
• Beobachtetes Molekulargewicht: 30-40 kDa, 90 kDa
• GenBank-Zugangsnummer: BC009704
• Gene symbol: TSPAN5
• Gene ID (NCBI): 10098
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TSPAN5 is a membrane protein of the tetraspanin superfamily, which are characterized by the presence of four conserved transmembrane regions. Tetraspanins have been involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, and cancer. TSPAN5 belongs to the TSPANC8 subfamily, which also include TSPAN10, TSPAN14, TSPAN15, TSPAN17, and TSPAN33. It has been reported that TSPANC8 tetraspanins interact with ADAM10 and have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch receptor activation (PMID: 23091066; 23035126).

Publikationen

Species	Application	Title
human	WB	Nat Commun; Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA; Authors - Mirjana Malnar Črnigoj
human	WB	Heliyon; Susceptibility of TSPAN5 polymorphisms to Kawasaki disease and immunoglobulin therapy resistance in southern Chinese children; Authors - Kaining Chen